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KMID : 1123920040180061810
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Korean Journal of Oriental Physiology and Pathology
2004 Volume.18 No. 6 p.1810 ~ p.1820
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Effects of Ramulus et Uncus Uncariae DM fraction on CT105-injuried Neuronal Cells
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Jang Hyun-Ho
Choi Hyuk
Yang Hyun-Duk
Kim Sang-Tae
Kim Tae-Heon
Kang Hyung-Won
Lyu Yeoung-Su
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Abstract
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The purpose of this study was to estimate the effects of Ramulus et Uncus Uncariae DM fraction on CT105-injuried neuronal cells. We were examined by ROS formation, neurite outgrowth assay and DPPH scravage assay. Additionally, we investigated the association between the CT105 and neurite degeneration caused by CT105-induced apoptotic response in neurone cells. We studied on the regeneratory and inhibitory effects of anti-Alzheimer disease in pCT105-induced neuroblastoma cell lines by REUD. Findings from our experiments have shown that REUD inhibits the synthesis or activities of CT105, which has neurotoxityies and apoptotic activities in cell line. In addition, treatment of REUD(>50㎍/㎖ for 12 hours) partially prevented CT105-induced cytotoxicity in SK-N-SH cell lines, and were inhibited by the treatment with its. REUD(>50㎍/㎖ for 12 hours) repaired CT105-induced neurite outgrowth when SK-N-SH cell lines was transfected with CT105. As the result of this study, In REUD group, the apoptosis in the nervous system was inhibited, the repai: against the degeneration of Neuroblastoma cells by CT105 expression was promoted. Base on these findings, REUD may be beneficial for the treatment of AD.
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KEYWORD
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Alzheimer’s disease, Ramulus et Uncus Uncariae(REUD), CT105
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